BDBM50279151 CHEMBL2431434

SMILES COc1cc(ccc1-n1cnc(C)c1)-c1noc2c1CCCC2(O)c1cc(F)cc(F)c1

InChI Key InChIKey=KIAJKLFNONPITC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50279151   

TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50279151(CHEMBL2431434)
Affinity DataIC50: 190nMAssay Description:Modulation of gamma-secretase (unknown origin) expressed in HEK293 cells harboring SCP99-Lon mutation assessed as reduction in Abeta42 production aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50279151(CHEMBL2431434)
Affinity DataIC50: 190nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells expressing APP after 5 hrs by sandwich immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed