BDBM50279080 (Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylicAcid Methyl Ester::CHEMBL502835::methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

SMILES CN1CCN(CC1)CC(=O)N(C)c2ccc(cc2)N/C(=C\3/c4ccc(cc4NC3=O)C(=O)OC)/c5ccccc5

InChI Key InChIKey=XZXHXSATPCNXJR-UHFFFAOYSA-N

Data  52 IC50  2 Kd

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 50279080   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 2.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Plk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 156nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 104nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 85nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas for Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
University of Arkansas for Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 8.26E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 6.03E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 7.25E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 7.08E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.35E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human insulin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Mouse)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 108nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Institute of Respiratory Health

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Boehringer Ingelheim Austria

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
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