BDBM50278662 CHEMBL4172540

SMILES C[C@@H](COc1ccn(-c2ccc(F)cc2)c(=O)c1)Oc1ccccc1

InChI Key InChIKey=AUMJXOXUSGIUCB-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50278662   

TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat mGlu2 receptor expressed in HEK293 cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 245nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 245nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 15 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 245nMAssay Description:Negative allosteric modulation of rat mGlu3R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278662(CHEMBL4172540)
Affinity DataIC50: 1.28E+3nMAssay Description:Negative allosteric modulation of rat mGlu3R expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed