BDBM50278654 CHEMBL4174544::US10399948, Compound 15

SMILES Fc1ccc(cc1F)-n1ccc(OCCOc2ccccc2)nc1=O

InChI Key InChIKey=RLBBKIIKOLHGAP-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50278654   

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278654(CHEMBL4174544 | US10399948, Compound 15)
Affinity DataEC50:  430nMAssay Description:Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278654(CHEMBL4174544 | US10399948, Compound 15)
Affinity DataIC50: 1.02E+3nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278654(CHEMBL4174544 | US10399948, Compound 15)
Affinity DataIC50: 1.02E+3nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278654(CHEMBL4174544 | US10399948, Compound 15)
Affinity DataEC50:  398nMAssay Description:Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278654(CHEMBL4174544 | US10399948, Compound 15)
Affinity DataIC50: 219nMAssay Description:Gα15/TREx cells stably expressing rat mGlu3 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Rat)
Vanderbilt University

US Patent
LigandPNGBDBM50278654(CHEMBL4174544 | US10399948, Compound 15)
Affinity DataIC50: 3.00E+4nMAssay Description:Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50278654(CHEMBL4174544 | US10399948, Compound 15)
Affinity DataIC50: 427nMAssay Description:HEK 293A cells stably expressing rat mGlu5 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent