BDBM50278432 (S)-6-((pyrrolidin-3-yloxy)methyl)-2-naphthonitrile::CHEMBL469810

SMILES N#Cc1ccc2cc(CO[C@H]3CCNC3)ccc2c1

InChI Key InChIKey=KZMOSMDAUNHNBH-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50278432   

TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278432((S)-6-((pyrrolidin-3-yloxy)methyl)-2-naphthonitril...)
Affinity DataIC50: 3nMAssay Description:Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278432((S)-6-((pyrrolidin-3-yloxy)methyl)-2-naphthonitril...)
Affinity DataIC50: 861nMAssay Description:Inhibition of radiolabeled dopamine reuptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50278432((S)-6-((pyrrolidin-3-yloxy)methyl)-2-naphthonitril...)
Affinity DataKi:  4.50E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50278432((S)-6-((pyrrolidin-3-yloxy)methyl)-2-naphthonitril...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of radiolabeled noradrenaline reuptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed