BDBM50278299 1-(6-(7-chloroquinazolin-4-yloxy)pyridin-3-yl)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)urea::CHEMBL471230

SMILES COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(Cl)ccc34)nc2)cc1OC1CCCC1

InChI Key InChIKey=CMDAQLXZGWQKFG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50278299   

TargetSUMO-activating enzyme subunit 1/2(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50278299(1-(6-(7-chloroquinazolin-4-yloxy)pyridin-3-yl)-3-(...)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of SUMO E1 (unknown origin)-mediated RanGAP1 sumoylation by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNH(3)-dependent NAD(+) synthetase(Bacillus anthracis)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50278299(1-(6-(7-chloroquinazolin-4-yloxy)pyridin-3-yl)-3-(...)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of Bacillus anthracis NAD synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSUMO-activating enzyme subunit 1(Human)
Riken

Curated by ChEMBL
LigandPNGBDBM50278299(1-(6-(7-chloroquinazolin-4-yloxy)pyridin-3-yl)-3-(...)
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of recombinant GST-fused SUMO E1 (unknown origin) using RanGAP1 as substrate after 2 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2017
Entry Details Article
PubMed