BDBM50278167 CHEMBL511475::N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide, 72::N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide::N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)naphthalene-2-carboxamide

SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1

InChI Key InChIKey=FAIFAFUXFFWVNQ-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50278167   

TargetPhospholipase D1(Human)
Vanderbilt University

LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataIC50: 5.10E+3nMT: 2°CAssay Description:PLD in vitro enzymatic assay using phospholipase D1(PLD1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University

LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataIC50: 140nMT: 2°CAssay Description:PLD in vitro enzymatic assay using phospholipase D2(PLD2).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University

LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University

LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataEC50:  1.00E+3nMT: 2°CAssay Description:cell-based assay using human non-small-cell lung cancer cell line, Calu-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University

LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataEC50:  110nMT: 2°CAssay Description:cell-based assay using HEK293-gfpPLD2 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2011
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University

LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PLD1 in human Calu1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataIC50: 110nMAssay Description:Inhibition of GFP-labeled PLD2 in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPhospholipase D1(Human)
Vanderbilt University

LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PLD1 in human calu1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPhospholipase D2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50278167(N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human GST-tagged PLD2A in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed