BDBM50278013 CHEMBL4166887

SMILES Oc1nnn(Cc2ccccc2)c1C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=UHUYUGANTDDPEB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50278013   

TargetAldo-keto reductase family 1 member C3(Human)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50278013(CHEMBL4166887)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 (DE) using [14C]androstenedione as substrate in presence of NADPH generatin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C2(Human)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50278013(CHEMBL4166887)
Affinity DataIC50: 6.29E+4nMAssay Description:Inhibition of AKR1C2 (unknown origin) using S-tetralol as substrate by by fluorimteryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50278013(CHEMBL4166887)
Affinity DataIC50: 480nMAssay Description:Inhibition of AKR1C3 (unknown origin) using S-tetralol as substrate in presence of NADP+ by fluorimteryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50278013(CHEMBL4166887)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
University of Torino

Curated by ChEMBL
LigandPNGBDBM50278013(CHEMBL4166887)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed