BDBM50277623 CHEMBL451523::N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinomethyl)pyridin-3-yl)naphthalen-1-yl)ureido)phenyl)methanesulfonamide::N-{5-tert-butyl-2-methoxy-3-[({4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl}carbamoyl)amino]phenyl}methanesulfonamide

SMILES COc1c(NC(=O)Nc2ccc(-c3ccc(CN4CCOCC4)nc3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C

InChI Key InChIKey=KLPFPTSVYVEKOL-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50277623   

TargetTyrosine-protein kinase ABL1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 480nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of bRafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 880nMAssay Description:Inhibition of crafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of ECKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of HEKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JNK2alpha2 by by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(N-(5-tert-butyl-2-methoxy-3-(3-(4-(6-(morpholinome...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of PKBalpha/Akt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed