BDBM50277584 CHEMBL482968::N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine
SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(C=Cc2ccccc2)n1
InChI Key InChIKey=BLQYVHBZHAISJM-UHFFFAOYSA-N
Data 34 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50277584
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant human FLT3More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human full length His-tagged Aurora A expressed in baculovirus expression system using peptide substrate after 1 hr by Z'-L...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant full length His-tagged human aurora A using peptide substrate in presence of ATP at its Km concentration by Z-lyte kinase a...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged VEGFR 2 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Vichem Chemie Research
Curated by ChEMBL
Vichem Chemie Research
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GST-tagged RET expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged FMS expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full length His-tagged Src expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GST-tagged PDGFR alpha (550 to 1089 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant human full length His-tagged Aurora B expressed in baculovirus expression system using peptide substrate after 1 hr by Z'-L...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human Aurora AMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human Aurora A using peptide substrate in presence of ATP at its Km concentration by Z-lyte kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora A (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 294nMAssay Description:Inhibition of Aurora B (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using FAM-labeled peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 81nMAssay Description:Inhibition of Abl T315I mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Binding affinity to PDGFRAMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of CSF-stimulated CSF1R phosphorylation in human MV4-11 cells by immunoblotting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair