BDBM50277584 CHEMBL482968::N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine

SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(C=Cc2ccccc2)n1

InChI Key InChIKey=BLQYVHBZHAISJM-UHFFFAOYSA-N

Data  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50277584   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human full length His-tagged Aurora A expressed in baculovirus expression system using peptide substrate after 1 hr by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant full length His-tagged human aurora A using peptide substrate in presence of ATP at its Km concentration by Z-lyte kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged VEGFR 2 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GST-tagged RET expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged FMS expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full length His-tagged Src expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GST-tagged PDGFR alpha (550 to 1089 residues) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant human full length His-tagged Aurora B expressed in baculovirus expression system using peptide substrate after 1 hr by Z'-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human Aurora A using peptide substrate in presence of ATP at its Km concentration by Z-lyte kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Aurora A (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 294nMAssay Description:Inhibition of Aurora B (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human Aurora A (1 to 403 residues) expressed in Escherichia coli using FAM-labeled peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 350nMAssay Description:Inhibition of aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 295nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 81nMAssay Description:Inhibition of Abl T315I mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 56nMAssay Description:Binding affinity to PDGFRAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of cKITMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 290nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 93nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 55nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 290nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Vichem Chemie Research

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CSF-stimulated CSF1R phosphorylation in human MV4-11 cells by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed