BDBM50277570 (4R,5S)-5-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)-2-pyrazin-2-yloctahydro-1H-isoindole::CHEMBL445239

SMILES C[C@@H](O[C@H]1CC[C@@H]2CN(C[C@H]2[C@@H]1c1ccc(F)cc1)c1cnccn1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=LZWZHVNWDDYRHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50277570   

TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277570((4R,5S)-5-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]...)
Affinity DataIC50: 0.525nMAssay Description:Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277570((4R,5S)-5-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]...)
Affinity DataIC50: 73nMAssay Description:Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed