BDBM50277437 CHEMBL512863::N-(3-methyl-4-(trifluoromethyl)phenyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide

SMILES Cc1cc(NC(=O)c2nscc2NCc2ccncc2)ccc1C(F)(F)F

InChI Key InChIKey=NMPXQVMGSSZQOY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277437   

LigandPNGBDBM50277437(N-(3-methyl-4-(trifluoromethyl)phenyl)-4-(pyridin-...)
Affinity DataIC50: 670nMAssay Description:Inhibition of VEGFR1 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277437(N-(3-methyl-4-(trifluoromethyl)phenyl)-4-(pyridin-...)
Affinity DataIC50: 710nMAssay Description:Inhibition of VEGFR2 expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50277437(N-(3-methyl-4-(trifluoromethyl)phenyl)-4-(pyridin-...)
Affinity DataIC50: 490nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed