BDBM50277118 (1S,16R)-13-(cyclopropylmethyl)-1,16-dimethyl-4,5,6,13-tetraazatetracyclo[10.3.1.0^{2,10}.0^{3,7}]hexadeca-2,4,7,9-tetraene::CHEMBL475108

SMILES C[C@H]1C2Cc3ccc4nn[nH]c4c3[C@@]1(C)CCN2CC1CC1

InChI Key InChIKey=CZRWDWGQXCPHDZ-UHFFFAOYSA-N

Data  3 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277118   

TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50277118((1S,16R)-13-(cyclopropylmethyl)-1,16-dimethyl-4,5,...)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50277118((1S,16R)-13-(cyclopropylmethyl)-1,16-dimethyl-4,5,...)
Affinity DataIC50: 99nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50277118((1S,16R)-13-(cyclopropylmethyl)-1,16-dimethyl-4,5,...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50277118((1S,16R)-13-(cyclopropylmethyl)-1,16-dimethyl-4,5,...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50277118((1S,16R)-13-(cyclopropylmethyl)-1,16-dimethyl-4,5,...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]Naltrindole from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed