BDBM50276964 CHEMBL462315::N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(pyridin-4-ylmethylamino)isothiazole-3-carboxamide

SMILES O=C(NCc1ccc2OCOc2c1)c1nscc1NCc1ccncc1

InChI Key InChIKey=KMQBYEYISLSNDK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50276964   

LigandPNGBDBM50276964(N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(pyridin-4-yl...)
Affinity DataIC50: 700nMAssay Description:Inhibition of VEGFR1 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50276964(N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(pyridin-4-yl...)
Affinity DataIC50: 790nMAssay Description:Inhibition of VEGFR2 expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50276964(N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(pyridin-4-yl...)
Affinity DataIC50: 650nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed