BDBM50276797 CHEMBL4174856

SMILES CN1CC[C@H]([C@H](F)C1)N1C(=O)S\C(=C/c2ccc3n(Cc4ccc(Cl)cc4C(F)(F)F)ncc3c2)C1=O

InChI Key InChIKey=BQNYTHNYGPJDQV-UHFFFAOYSA-N

Data  12 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50276797   

TargetRetinoic acid receptor beta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant GST-tagged human RARbeta LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant GST-tagged human LXRbeta LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant GST-tagged human PPARalpha LBD assessed as inhibition of GW7647-induced fluorescein-labeled coactivator peptide re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant GST-tagged human RXRalpha LBD assessed as inhibition of 9-cis-retinoic acid-induced fluorescein-labeled coactivato...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant GST-tagged human LXRalpha LBD assessed as inhibition of TO901317-induced fluorescein-labeled coactivator peptide r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant GST-tagged human PPARdelta LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetEstrogen-related receptor gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at ERRgamma (unknown origin) assessed as inhibition of co-activator peptide recruitment by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant GST-tagged human ERRbeta LBD assessed as inhibition of fluorescein-labeled coactivator peptide recruitment preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at recombinant GST-tagged human LXRbeta LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetSteroid hormone receptor ERR1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at His6-tagged ERRalpha LBD (unknown origin) assessed as inhibition of GST-tagged SRC-2 co-activator peptide recruitment after 18...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant GST-tagged human PPARalpha LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of fluormone PPARgamma Green binding to recombinant N-terminal GST-tagged human PPARgamma LBD by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-beta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant GST-tagged human RXRbeta LBD assessed as inhibition of all-trans-retinoic acid-induced fluorescein-labeled coactiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant GST-tagged human PPARdelta LBD assessed as inhibition of GW0742-induced fluorescein-labeled coactivator peptide re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of fluormone ES2 binding to recombinant full length human ERbeta expressed in insect cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant GST-tagged human LXRalpha LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at recombinant GST-tagged human RXRalpha LBD assessed as fluorescein-labeled coactivator peptide recruitment preincubated with enzym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50276797(CHEMBL4174856)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of fluormone ES2 green binding to recombinant full length human ERalpha expressed in insect cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details Article
PubMed