BDBM50276157 Alternariol 5-O-Methyl Ether::CHEMBL483526

SMILES COc1cc(O)c2c(c1)c1c(C)cc(O)cc1oc2=O

InChI Key InChIKey=LCSDQFNUYFTXMT-UHFFFAOYSA-N

Data  1 KI  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50276157   

TargetCasein kinase II subunit alpha(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 3.67E+4nMAssay Description:Inhibition of recombinant CK2alpha1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 6.61E+3nMAssay Description:Inhibition of recombinant PDGFRbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 9.18E+3nMAssay Description:Inhibition of recombinant SAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 3.67E+3nMAssay Description:Inhibition of recombinant FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 4.04E+3nMAssay Description:Inhibition of recombinant VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 5.14E+3nMAssay Description:Inhibition of recombinant EPHB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 4.77E+3nMAssay Description:Inhibition of recombinant Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 3.01E+4nMAssay Description:Inhibition of recombinant PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of recombinant INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 7.71E+3nMAssay Description:Inhibition of recombinant CDK4/CycD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of recombinant CDK2/CycAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of recombinant Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of recombinant ARK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 9.54E+3nMAssay Description:Inhibition of recombinant COTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of recombinant B-RAF-V600E mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of recombinant VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of recombinant SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of recombinant IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of recombinant AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 3.26E+4nMAssay Description:Inhibition of recombinant FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of recombinant ERBB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 3.67E+4nMAssay Description:Inhibition of recombinant METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Heinrich-Heine-Universit£T

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of recombinant TIE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Jamia Millia Islamia

Curated by ChEMBL
LigandPNGBDBM50276157(CHEMBL483526 | Alternariol 5-O-Methyl Ether)
Affinity DataKi:  340nMAssay Description:Mixed type inhibition of human MAO-A assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed