BDBM50276143 CHEMBL4128547

SMILES CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(O)=O

InChI Key InChIKey=UEYXMOTVZNZSMM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50276143   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human SIRT1 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of sirtuin 6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed