BDBM50276098 CHEMBL4127317

SMILES COc1cc(ccc1Nc1ncc2c(n1)n(-c1cccc(NC(=O)C=C)c1)c(=O)n(C(C)C)c2=O)N1CCN(C)CC1

InChI Key InChIKey=RLWORZOMJGXPLR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50276098   

TargetCytochrome P450 3A4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 2.39E+4nMAssay Description:Inhibition of human CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expressed in baculovirus expression system using Poly(Glu,Tyr)4:1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system using Poly(Glu,Tyr)4:1 as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50276098(CHEMBL4127317)
Affinity DataIC50: 518nMAssay Description:Inhibition of BTK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed