BDBM50275926 CHEMBL4128173

SMILES COc1ccc(Cl)cc1C[C@@H]1CNC(CN(CC(=O)Nc2cccc(c2)C(O)=O)C1=O)=N/N(C)C

InChI Key InChIKey=STRUTOBZXDUGAL-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50275926   

TargetKallikrein-7(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50275926(CHEMBL4128173)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human C-terminal His10-tagged KLK7 (E23 to H252 residues) using MOCAcArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-7(Mouse)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50275926(CHEMBL4128173)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mouse KLK7 using MOCAcArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50275926(CHEMBL4128173)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human trypsin preincubated for 10 mins followed by Boc-Gln-Ala-Arg-MCA peptide substrate addition measured after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetKallikrein-5(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50275926(CHEMBL4128173)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged KLK5 preincubated for 10 mins followed by Boc-Val-Pro-Arg-MCA peptide substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetKallikrein-7(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50275926(CHEMBL4128173)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of thermolysin activated recombinant human C-terminal 10-His tagged KLK7 preincubated for 10 mins followed by MOCAc-Arg-Pro-Lys-Pro-Val-Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKallikrein-7(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50275926(CHEMBL4128173)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human KLK7 using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)