BDBM50275356 3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-ylamino)-5-(trifluoromethyl)phenol::CHEMBL485730

SMILES OCc1csc(n1)-c1ccnc(Nc2cc(O)cc(c2)C(F)(F)F)n1

InChI Key InChIKey=CXXHIMHTNIDPAR-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50275356   

TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50275356(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of SYK-mediated FCepsilonRI signaling activity by mast cell degranulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50275356(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Affinity DataKi:  50nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50275356(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Affinity DataKi:  680nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50275356(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50275356(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed