BDBM50275324 5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-(6,7-dimethoxy-3,4-dihydroisoquinoline)::CHEMBL519547

SMILES COc1cccc(CCc2ccccc2OCCCCCN2CCc3cc(OC)c(OC)cc3C2)c1

InChI Key InChIKey=UZHJKQAEGCHEJR-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50275324   

TargetATP-dependent translocase ABCB1(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275324(5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-(6,7...)
Affinity DataIC50: 350nMAssay Description:Inhibition of ABCB1-mediated [3H]vinblastine transportation in human Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275324(5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-(6,7...)
Affinity DataIC50: 110nMAssay Description:Inhibition of ABCB1 transfected in MDCK cells assessed as increase in calcein-AM accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275324(5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-(6,7...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]spiroperidol from human cloned dopaminergic D2 receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275324(5-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}propyl-(6,7...)
Affinity DataKi: >5.00E+6nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5-HT1A receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed