BDBM50275218 4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2'-pyrimidyl)piperazine::CHEMBL487760

SMILES COc1cccc(CCc2ccccc2OCCCCN2CCN(CC2)c2ncccn2)c1

InChI Key InChIKey=KBVKGDXJIDQBBH-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50275218   

TargetATP-dependent translocase ABCB1(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275218(4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2'...)
Affinity DataIC50: 200nMAssay Description:Inhibition of ABCB1-mediated [3H]vinblastine transportation in human Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275218(4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2'...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of ABCB1 transfected in MDCK cells assessed as increase in calcein-AM accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275218(4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2'...)
Affinity DataKi:  8.54E+5nMAssay Description:Displacement of [3H]spiroperidol from human cloned dopaminergic D2 receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275218(4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(2'...)
Affinity DataKi:  5.58E+5nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5-HT1A receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed