BDBM50275136 4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3'-trifluoromethylphenyl)piperazine::CHEMBL459158

SMILES COc1cccc(CCc2ccccc2OCCCCN2CCN(CC2)c2cccc(c2)C(F)(F)F)c1

InChI Key InChIKey=JGSPPIYFQDHZNR-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50275136   

TargetATP-dependent translocase ABCB1(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275136(4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3'-...)
Affinity DataIC50: 750nMAssay Description:Inhibition of ABCB1-mediated [3H]vinblastine transportation in human Caco-2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275136(4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3'-...)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of ABCB1 transfected in MDCK cells assessed as increase in calcein-AM accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275136(4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3'-...)
Affinity DataKi: >5.00E+6nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5-HT1A receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Universita Degli Studi Di Bari

Curated by ChEMBL
LigandPNGBDBM50275136(4{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}butyl-4-(3'-...)
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H]spiroperidol from human cloned dopaminergic D2 receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed