BDBM50275059 (Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one::CHEMBL463187

SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1csc2ccccc12

InChI Key InChIKey=KAXVKSGLOHAOQW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50275059   

TargetPerforin-1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50275059((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...)
Affinity DataIC50: 970nMAssay Description:Inhibition of recombinant perforin-mediated lysis of human Jurkat T cells by 51Cr release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPerforin-1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50275059((Z)-1-(Benzo[b]thiophen-3-ylmethylene)-6-methyl-4-...)
Affinity DataIC50: 970nMAssay Description:Inhibition of recombinant perforin mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed