BDBM50274729 CHEMBL4128945

SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(cc1)C(F)(F)F)C(=O)NCC(N)=O

InChI Key InChIKey=CZDZZPIQDHMNJS-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50274729   

TargetMu-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50274729(CHEMBL4128945)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at rat mu-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50274729(CHEMBL4128945)
Affinity DataEC50:  27nMAssay Description:Agonist activity at rat delta-opioid receptor expressed in HEK293 cells co-expressing Rluc2-EPAC-GFP10 biosenser assessed as inhibition of forskolin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50274729(CHEMBL4128945)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]-DAMGO from mouse Flag-tagged mu-opioid receptor expressed in HEK293 cell membranes after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50274729(CHEMBL4128945)
Affinity DataIC50: 1.30nMAssay Description:Agonist activity at mu-opioid receptor in guinea pig ileum assessed as inhibition of electrically induced contractionsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50274729(CHEMBL4128945)
Affinity DataIC50: 1.80nMAssay Description:Agonist activity at delta-opioid receptor in mouse vasa deferens assessed as inhibition of electrically induced contractionsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50274729(CHEMBL4128945)
Affinity DataIC50: 39nMAssay Description:Displacement of [125I]-Deltorphin 2 from mouse Flag-tagged delta-opioid receptor expressed in HEK293 cell membranes after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2020
Entry Details Article
PubMed