BDBM50274720 6-(2-aminophenoxy)benzo[d]isothiazol-3-amine::CHEMBL458612

SMILES Nc1nsc2cc(Oc3ccccc3N)ccc12

InChI Key InChIKey=HQCTTYOADNAJJR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274720   

TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274720(6-(2-aminophenoxy)benzo[d]isothiazol-3-amine | CHE...)
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50274720(6-(2-aminophenoxy)benzo[d]isothiazol-3-amine | CHE...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed