BDBM50274650 CHEMBL4130021

SMILES CNC(=O)c1nc(cnc1N)-c1cc2CN([C@@H](C)C3CC3)C(=O)c2c(C)c1

InChI Key InChIKey=ZXWFXYNECDHLJA-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50274650   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50274650(CHEMBL4130021)Copy SMILESCopy InChI

Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/13/2020
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50274650(CHEMBL4130021)Copy SMILESCopy InChI

Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate additi...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/13/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50274650(CHEMBL4130021)Copy SMILESCopy InChI

Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/13/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50274650(CHEMBL4130021)Copy SMILESCopy InChI

Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/13/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mouse)
Pharmaron-Beijing

Curated by ChEMBL

LigandBDBM50274650(CHEMBL4130021)Copy SMILESCopy InChI

Affinity DataIC50: 398nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 15 mins followed by C5a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/13/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL