BDBM50274641 CHEMBL4126010::US10858355, Example 27

SMILES COCCS(=O)(=O)Nc1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(NC(C)=O)nc1C

InChI Key InChIKey=CYXPQVSTQNRNSH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50274641   

LigandPNGBDBM50274641(CHEMBL4126010 | US10858355, Example 27)
Affinity DataIC50: 251nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50274641(CHEMBL4126010 | US10858355, Example 27)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50274641(CHEMBL4126010 | US10858355, Example 27)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50274641(CHEMBL4126010 | US10858355, Example 27)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 15 mins followed by C5a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50274641(CHEMBL4126010 | US10858355, Example 27)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50274641(CHEMBL4126010 | US10858355, Example 27)
Affinity DataIC50: 1nMAssay Description:The activity of recombinant human PI3Kγ (aa144-1102)-6His was determined by measuring the ADP level after phosphorylation of DiC8-PIP2 using a c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent