BDBM50274535 CHEMBL4126250

SMILES CCNC(=O)c1noc(c1NC(=O)c1ccc(cc1)C(=O)NC(N)=N)-c1cc(C(C)C)c(O)cc1O

InChI Key InChIKey=QOJWFEQFNRMAGF-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50274535   

TargetHeat shock protein 75 kDa, mitochondrial(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50274535(CHEMBL4126250)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged TRAP1 (60 to 704 residues) ATPase activity expressed in Escherichia coli BL21-CodonPlus-RIL af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50274535(CHEMBL4126250)
Affinity DataKd:  10nMAssay Description:Inhibition of FITC-geldanamycin binding to recombinant human N-terminal His6-tagged TRAP1 (60 to 704 residues) expressed in Escherichia coli BL21-Cod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50274535(CHEMBL4126250)
Affinity DataKd:  1.5nMAssay Description:Inhibition of FITC-geldanamycin binding to recombinant human HSP90alpha expressed in Escherichia coli by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50274535(CHEMBL4126250)
Affinity DataIC50: 21nMAssay Description:Inhibition of FITC-geldanamycin binding to recombinant human HSP90alpha expressed in Escherichia coli by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2020
Entry Details Article
PubMed