BDBM50274124 CHEMBL4125966::US10793591, Compound 12

SMILES O[C@@H]1[C@@](F)(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@@H](n2ccc(=O)[nH]c2=O)[C@@]1(O)C#C

InChI Key InChIKey=UURYKGMKMQDJFA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50274124   

TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274124(CHEMBL4125966 | US10793591, Compound 12)
Affinity DataIC50: 650nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Biopharma

Curated by ChEMBL
LigandPNGBDBM50274124(CHEMBL4125966 | US10793591, Compound 12)
Affinity DataIC50: 39nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase activity assessed as reduction in radiolabeled-UTP incorporation into RNA using cIRES template me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGenome polyprotein [1973-2419](HCV)
Janssen Biopharma

US Patent
LigandPNGBDBM50274124(CHEMBL4125966 | US10793591, Compound 12)
Affinity DataIC50: 1.00E+3nMAssay Description:The enzyme activity of NS5B570-Con1 (Delta-21) was measured as an incorporation of tritiated NMP into acid-insoluble RNA products. The complementary ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent