BDBM50274115 CHEMBL4127372::US10550089, Example 2::US10995072, Example 3

SMILES CCCc1cc(ccc1[C@@H](c2[nH]ccn2)O)F

InChI Key InChIKey=IDFPQEHZYBXIFO-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50274115   

TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274115(CHEMBL4127372 | US10550089, Example 2 | US10995072...)
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at PAR2 in human 1321N1 cells assessed as inhibition of trypsin-induced intracellular calcium flux pretreated for 60 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274115(CHEMBL4127372 | US10550089, Example 2 | US10995072...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274115(CHEMBL4127372 | US10550089, Example 2 | US10995072...)
Affinity DataIC50: 4.10E+4nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274115(CHEMBL4127372 | US10550089, Example 2 | US10995072...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274115(CHEMBL4127372 | US10550089, Example 2 | US10995072...)
Affinity DataIC50: 3.92E+3nMAssay Description:Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)