BDBM50274114 CHEMBL4128763

SMILES C[C@@H](C1CCCCC1)n1c(nc2cc(ccc12)C(=O)Nc1ccc(cc1)C#N)-c1cc2OCOc2cc1Br

InChI Key InChIKey=FJAOGFGHTPYADT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50274114   

TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274114(CHEMBL4128763)
Affinity DataIC50: 6.60E+3nMAssay Description:Antagonist activity at PAR2 in human 1321N1 cells assessed as inhibition of trypsin-induced intracellular calcium flux pretreated for 60 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed
TargetProteinase-activated receptor 4(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50274114(CHEMBL4128763)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human PAR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274114(CHEMBL4128763)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human PAR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50274114(CHEMBL4128763)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at human PAR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274114(CHEMBL4128763)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at PAR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed