BDBM50273812 CHEMBL4125752

SMILES Cn1cc(cn1)-c1ccc(cc1)-c1ccc(cc1)C1=NC2(CC2)C(=O)N1C[C@@H]1CCN(C1)C(=O)C1CC1

InChI Key InChIKey=VXNJFKPHXOAQEY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50273812   

TargetCytochrome P450 2C8(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 28nMAssay Description:Inhibition of human full length FASN using [3H]-acetyl-CoA/malonyl-CoA as substrate after 60 mins in presence of NADPH by scintillation proximity ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50273812(CHEMBL4125752)
Affinity DataIC50: 54nMAssay Description:Inhibition of human FASN KR-domain after 20 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2020
Entry Details Article
PubMed