BDBM50273553 CHEMBL4127020::US10508088, ID HDTK028::US11535607, Example 17-1

SMILES CC1(C)N(Cc2c1cccc2C(=O)NO)c1nc2ccc(cc2[nH]1)C(F)(F)F

InChI Key InChIKey=ASSXNRYAUYXUGB-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50273553   

TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
Forma Therapeutics

US Patent
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 1.00E+4nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 3nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 500nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 500nMAssay Description:The measurement of HD AC 11 deacetylase activity was performed using an electrophoretic mobility shift assay by Nanosyn (Santa Clara, Calif.). Full l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent