BDBM50273540 CHEMBL4127193::US11535607, Example 1-6

SMILES ONC(=O)c1cccc2CN(Cc12)c1nc2ccccc2[nH]1

InChI Key InChIKey=WPCDPURYAICIPJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50273540   

TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273540(CHEMBL4127193 | US11535607, Example 1-6)
Affinity DataIC50: 170nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273540(CHEMBL4127193 | US11535607, Example 1-6)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC6 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273540(CHEMBL4127193 | US11535607, Example 1-6)
Affinity DataIC50: 1.00E+3nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273540(CHEMBL4127193 | US11535607, Example 1-6)
Affinity DataIC50: 500nMAssay Description:The measurement of HD AC 11 deacetylase activity was performed using an electrophoretic mobility shift assay by Nanosyn (Santa Clara, Calif.). Full l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273540(CHEMBL4127193 | US11535607, Example 1-6)
Affinity DataIC50: 1.00E+3nMAssay Description:The measurement of HD AC 11 deacetylase activity was performed using an electrophoretic mobility shift assay by Nanosyn (Santa Clara, Calif.). Full l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50273540(CHEMBL4127193 | US11535607, Example 1-6)
Affinity DataIC50: 1.00E+3nMAssay Description:The measurement of HD AC 11 deacetylase activity was performed using an electrophoretic mobility shift assay by Nanosyn (Santa Clara, Calif.). Full l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent