BDBM50273526 CHEMBL4126661::US11535607, Example 22-8

SMILES CC1(C)N(Cc2c1cccc2C(=O)NO)c1cnc(cn1)C(F)(F)F

InChI Key InChIKey=XCLPBILTRRWOIL-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50273526   

TargetHistone deacetylase 1(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 500nMAssay Description:The measurement of HD AC 11 deacetylase activity was performed using an electrophoretic mobility shift assay by Nanosyn (Santa Clara, Calif.). Full l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 500nMAssay Description:The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 500nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 9(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 7(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 5(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity was measured using electrophoretic mobility shift assays with full length human recombinant HDAC proteins and fluorescently labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 4(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC4 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of full length recombinant human HDAC8 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC6 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC9 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC7 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC5 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC2 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC1 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 15nMAssay Description:Inhibition of NanoLuc-tagged HDAC11 (unknown origin) by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC3 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Valo Health

US Patent
LigandPNGBDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human HDAC10 using fluorescent-labeled peptide as substrate by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed