BDBM50273345 CHEMBL4129988

SMILES Nc1cccnc1N1CCC(CC1)C(=O)Nc1ccc(F)c(Cl)c1

InChI Key InChIKey=LYPFTOMNPDGATJ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273345   

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273345(CHEMBL4129988)
Affinity DataIC50: 420nMAssay Description:Inhibition of cIAP2 fused MALT1 (unknown origin) expressed in HEK293 cells assessed as suppression of NF-kB activation after 24 hrs by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273345(CHEMBL4129988)
Affinity DataEC50:  540nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed a decrease in BCL10 cleavage after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273345(CHEMBL4129988)
Affinity DataIC50: 100nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg'Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2020
Entry Details Article
PubMed