BDBM50273292 (R)-N-(1-(1,4'-bipiperidin-1'-yl)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamide::CHEMBL2336410::CHEMBL454791

SMILES Cc1cc(C[C@@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C(=O)N2CCC(CC2)N2CCCCC2)cc2cn[nH]c12

InChI Key InChIKey=MMNFZCWXLBJTKN-UHFFFAOYSA-N

Data  3 KI  10 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50273292   

TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of recombinant CYP3A4 expressed in insect microsomes after 45 mins in presence of BZR substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) expressed in insect microsomes after 20 mins in presence of BFC substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-resorufin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-resorufin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataEC50:  0.0170nMAssay Description:Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of CCRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataKi:  0.00730nMAssay Description:Binding affinity to CGRP receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [I125]CGRP from human CGRP receptor in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50273292(CHEMBL2336410 | CHEMBL454791 | (R)-N-(1-(1,4'-bipi...)
Affinity DataKi:  0.0120nMAssay Description:Binding affinity to CGRP receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed