BDBM50273281 CHEMBL456375::CHEMBL543669::N-methyl-4-anilino-6,7-dimethoxyquinazoline

SMILES COc1cc2ncnc(N(C)c3ccccc3)c2cc1OC

InChI Key InChIKey=FPYMICFLRIEXEX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50273281   

LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50: 500nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of p56 lck tyrosine kinase (inactive)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of p56lck kinase autophosphorylation in Jurkat cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

LigandPNGBDBM50273281(CHEMBL456375 | CHEMBL543669 | N-methyl-4-anilino-6...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor (PDGF-R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article