BDBM50273216 2-cyano-4-((4,4-difluorocyclohexyl)methylamino)-N-phenethylpyrimidine-5-carboxamide::CHEMBL456755

SMILES FC1(F)CCC(CNc2nc(ncc2C(=O)NCCc2ccccc2)C#N)CC1

InChI Key InChIKey=YEOKXFGVPJIODJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273216   

TargetProcathepsin L(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273216(2-cyano-4-((4,4-difluorocyclohexyl)methylamino)-N-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant cathepsin L by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273216(2-cyano-4-((4,4-difluorocyclohexyl)methylamino)-N-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant cathepsin K by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273216(2-cyano-4-((4,4-difluorocyclohexyl)methylamino)-N-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed