BDBM50273065 (E)-2-(1-(Biphenyl-4-ylmethylene)-5-fluoro-1H-inden-3-yl)ethanoic acid::CHEMBL457404

SMILES OC(=O)CC1=C\C(=C/c2ccc(cc2)-c2ccccc2)c2ccc(F)cc12

InChI Key InChIKey=VJDZAFANKNWYHT-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50273065   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Vanderbilt University Center For Structural Biology

Curated by ChEMBL
LigandPNGBDBM50273065((E)-2-(1-(Biphenyl-4-ylmethylene)-5-fluoro-1H-inde...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Vanderbilt Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50273065((E)-2-(1-(Biphenyl-4-ylmethylene)-5-fluoro-1H-inde...)
Affinity DataIC50: 300nMAssay Description:Inhibition of COX-1 in human OVCAR3 cells using [14C] arachidonic acid as substrate preincubated for 30 mins before substrate addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Vanderbilt Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50273065((E)-2-(1-(Biphenyl-4-ylmethylene)-5-fluoro-1H-inde...)
Affinity DataIC50: 570nMAssay Description:Inhibition of ovine COX-1 using [14C] arachidonic acid as substrate preincubated for 17 mins before substrate addition measured after 3 mins by thin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Vanderbilt Institute of Chemical Biology

Curated by ChEMBL
LigandPNGBDBM50273065((E)-2-(1-(Biphenyl-4-ylmethylene)-5-fluoro-1H-inde...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse COX-2 using [14C] arachidonic acid as substrate preincubated for 17 mins before substrate addition measured after 3 mins by thin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed