BDBM50272787 CHEMBL4126658

SMILES CCn1ncc2CC(CCc12)Nc1nc2c(cccn2n1)-c1ccccc1Cl

InChI Key InChIKey=TZCXHOJPNBMDIP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50272787   

TargetPresenilin-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50272787(CHEMBL4126658)
Affinity DataIC50: 60nMAssay Description:Modulation of gamma secretase in human H4 cells expressing human wild type APP assessed as inhibition of amyloid beta 42 production after 22 hrs by e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50272787(CHEMBL4126658)
Affinity DataIC50: 60nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing human APP695 assessed as decrease in amyloid beta 42 production by electrochemiluminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed