BDBM50272786 5-Bromo-4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-6-[(spiro[2.5]oct-6-ylmethyl)-amino]-pyrimidine-2-carbonitrile::CHEMBL526107

SMILES CN1CCC(CCOc2nc(nc(NCC3CCC4(CC4)CC3)c2Br)C#N)CC1

InChI Key InChIKey=HJUPPNTXGDFNAO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272786   

TargetCathepsin K(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272786(5-Bromo-4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-6-[...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant cathepsin K by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272786(5-Bromo-4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-6-[...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant cathepsin L by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50272786(5-Bromo-4-[2-(1-methyl-piperidin-4-yl)-ethoxy]-6-[...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed