BDBM50272758 CHEMBL4127467

SMILES Cc1cc(F)ccc1-c1cccn2nc(Nc3ccc4n(C)ncc4c3)nc12

InChI Key InChIKey=JOBYUGHYDPKIRF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50272758   

TargetPresenilin-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50272758(CHEMBL4127467)
Affinity DataIC50: 1.20E+3nMAssay Description:Modulation of gamma secretase in human H4 cells expressing human wild type APP assessed as inhibition of amyloid beta 42 production after 22 hrs by e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50272758(CHEMBL4127467)
Affinity DataIC50: 1.20E+3nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human APP assessed as reduction in amyloid beta42 level incubated for 22 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed