BDBM50272737 CHEMBL4128121

SMILES CCn1ncc2CC(CCc12)Nc1nc2c(cccn2n1)-c1ccc(OC)nc1

InChI Key InChIKey=IIJCPDFRXNMOQQ-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50272737   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL

LigandBDBM50272737(CHEMBL4128121)Copy SMILESCopy InChI

Affinity DataIC50: 90nMAssay Description:Modulation of gamma secretase in human H4 cells expressing human wild type APP assessed as inhibition of amyloid beta 42 production after 22 hrs by e...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/3/2020
Entry Details Article
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TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL

LigandBDBM50272737(CHEMBL4128121)Copy SMILESCopy InChI

Affinity DataIC50: 90nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing human APP695 assessed as decrease in amyloid beta 42 production by electrochemiluminescenc...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/22/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL