BDBM50272533 CHEMBL4129030

SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2ccc(Cl)c(Cl)c2)cc1F

InChI Key InChIKey=RQIRAWYTRPXHHW-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50272533   

LigandPNGBDBM50272533(CHEMBL4129030)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells at holding potential of -50 mV followed by voltage step to -120 mV by PatchXpress electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50272533(CHEMBL4129030)
Affinity DataIC50: 76nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells clamped to holding potential yielding 20 to 50% inactivation by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50272533(CHEMBL4129030)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50272533(CHEMBL4129030)
Affinity DataIC50: 76nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50272533(CHEMBL4129030)
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed