BDBM50272530 CHEMBL4130208

SMILES Fc1cc(c(F)cc1-c1nnc([nH]1)S(=O)(=O)CC1CC1)-c1cnc(Oc2ccccc2C(F)(F)F)c(Cl)c1

InChI Key InChIKey=ARCUVPSLBZWKRK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272530   

LigandPNGBDBM50272530(CHEMBL4130208)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells clamped to holding potential yielding 20 to 50% inactivation assessed as reduction in peak sodium c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50272530(CHEMBL4130208)
Affinity DataIC50: 70nMAssay Description:Displacement of [3H]-6,6-fused heteroaryl-sulfonamide derivative from human Nav1.7 expressed in HEK293 cell membranes preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50272530(CHEMBL4130208)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells at holding potential of -50 mV followed by voltage step to -120 mV by PatchXpress electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed