BDBM50272524 CHEMBL4127756

SMILES CC(C)COc1ncc(cc1Cl)-c1cc(F)c(cc1F)-c1nnc([nH]1)S(=O)(=O)CC1CC1

InChI Key InChIKey=YAKUACDRCDWUNN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272524   

LigandPNGBDBM50272524(CHEMBL4127756)
Affinity DataIC50: 320nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells clamped to holding potential yielding 20 to 50% inactivation assessed as reduction in peak sodium c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50272524(CHEMBL4127756)
Affinity DataIC50: 149nMAssay Description:Displacement of [3H]-6,6-fused heteroaryl-sulfonamide derivative from human Nav1.7 expressed in HEK293 cell membranes preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50272524(CHEMBL4127756)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells at holding potential of -50 mV followed by voltage step to -120 mV by PatchXpress electrophysiology...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2020
Entry Details Article
PubMed