BDBM50272522 (11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl (1R)-1-phenylethylcarbamate::CHEMBL509182

SMILES C[C@@H](NC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CO)c1ccccc1

InChI Key InChIKey=BLPNJKOYOIDEJJ-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272522   

TargetGlucocorticoid receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272522((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine aminotransferase(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272522((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  70.3nMAssay Description:Transactivation activity of tyrosine amino transferase in rat H4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50272522((11beta,16beta)-9-Fluoro-11,21-dihydroxy-16-methyl...)
Affinity DataEC50:  21.5nMAssay Description:Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed