BDBM50272491 CHEMBL4126375

SMILES Fc1ccc(Oc2ncc(cc2Cl)-c2cc(F)c(cc2F)-c2nnc([nH]2)S(=O)(=O)CC2CC2)c(Cl)c1

InChI Key InChIKey=WQDSTRSXRJYKJI-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50272491   

TargetSodium channel protein type 5 subunit alpha(Human)
Amgen

Curated by ChEMBL

LigandBDBM50272491(CHEMBL4126375)Copy SMILESCopy InChI

Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells at holding potential of -50 mV followed by voltage step to -120 mV by PatchXpress electrophysiology...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/2/2020
Entry Details Article
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TargetSodium channel protein type 9 subunit alpha(Human)
Amgen

Curated by ChEMBL

LigandBDBM50272491(CHEMBL4126375)Copy SMILESCopy InChI

Affinity DataIC50: 190nMAssay Description:Inhibition of human Nav1.7 expressed in HEK cells clamped to holding potential yielding 20 to 50% inactivation assessed as reduction in peak sodium c...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/2/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL